WebMechanisms of action of bisphosphonates. Bisphosphonates (BPs) are pyrophosphate analogs in which the oxygen bridge has been replaced by carbon and diverse carbon … WebBisphosphonates are widely used in the treatment of diseases involving excessive bone resorption, such as osteoporosis, cancer-associated bone disease, and Paget's disease of bone. ... these concepts have been refined, with an increased understanding of the exact mode of inhibition of FPP synthase and the consequences of inhibiting this enzyme ...
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Webbisphosphonates are ingested by osteoclasts and work by two different methods depending on presence of nitrogen atom on the alkyl chain Nitrogen containing … WebJan 17, 2024 · This mode of action stands in stark contrast to that of antiresorptive agents (i.e., bisphosphonates, long-term estrogen, raloxifene, and nasal calcitonin). These agents inhibit osteoclast-mediated bone resorption and, by doing so, also inhibit new bone formation because the two processes of resorption and formation are tightly coupled … cities outside of las vegas nevada
Bisphosphonates: how do bisphosphonates work? Patient
WebEven though the promotion of osteoclasts’s apoptosis represents the main mechanism of action of bisphosphonates, 2 osteoblasts have been shown to play an important role in bone homeostasis as well. 32 These cells regulate bone metabolism by directly interacting with osteoclasts through direct cell-cell contact, cytokines and extracellular ... WebThe mechanism of action for suppressing bone resorption is the inhibition of farnesyl pyrophosphate synthase, a key enzyme in the mevalonic acid metabolic pathway of osteoclasts, to induce apoptosis of the cells. Minodronate is the strongest inhibitor of bone resorption among the currently available oral bisphosphonates. WebMany of the bisphosphonates are very powerful inhibitors of bone resorption. This is seen both in normal animals and in animals where bone resorption is simulated by various means. Thus, they are active in various models of human diseases, such as hyperparathyroidism, tumoral bone disease and osteoporosis. cities outside of la california