WebThe p-ATR expression increased in head and neck squamous cell carcinoma cisplatin-resistant cells. VE-822 significantly enhanced the therapeutic effect in cisplatin resistant head and neck squamous cell carcinoma by inhibiting p-ATR expression in vivo and in vitro. WebApr 24, 2024 · RNA interference (RNAi)-mediated depletion or inhibition of ATR has been shown to sensitize ovarian cancer cells to cisplatin, topotecan, gemcitabine, and the PARP inhibitor veliparib (ABT-888) [ 50 ]. Moreover, an ATR inhibitor further enhanced the killing of BRCA1-depleted ovarian cancer cells by cisplatin, topotecan, and veliparib [ 50 ].
IJMS Free Full-Text Multi-Level Control of the ATM/ATR-CHK1 …
WebJun 13, 2013 · ATR inhibition further sensitizes cells with defective HR to cisplatin, topotecan, and veliparib. A, OVCAR-8 cells that have stably integrated DR-GFP HR substrate were transfected with pCßA Sce I plasmid plus control (Luc) or ATR siRNA and examined for GFP fluorescence 72 hours after plasmid transfection. WebJan 12, 2016 · These results indicate that inhibiting ATR-Chk1 activation with WYC0209 suppresses p-glycoprotein expression and increases cisplatin activity in bladder cancer. Our findings collectively suggest that ATR-Chk1 is a target for improving the efficacy of cisplatin in bladder cancer. Keywords: ATR-Chk1; bladder cancer; natural products. can i play yandere simulator on xbox
Abstract LB301: Molecular pharmacology and broad synergy of …
WebThe effect of compounds 3a–d on the ATR-dependent phosphorylation of Chk1 was evaluated by western immunoblotting, as previously published . Briefly, MCF7 cells were pretreated with 1 µM of the compounds for 30 min and exposed to 10 µM cisplatin in the presence or absence of the compounds for 8 h to induce DDR. WebMay 12, 2015 · ATR inhibition synergizes with loss of ERCC1, ATM, XRCC1 and DNA damaging chemotherapy agents. Clinical trials have begun using ATR inhibitors in … WebCumulative Dose of Cisplatin in Patients Receiving Cisplatin and Gemcitabine With Berzosertib (Arm A) and Cisplatin and Gemcitabine Alone (Arm B) View LargeDownload Median doses are indicated with the horizontal bars; error bars represent interquartile ranges; each dot represents 1 patient. can i play youtube music on sonos