Cyclothialidine
WebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products. WebApr 1, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the...
Cyclothialidine
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WebCombining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Liane Saíz-Urra, Miguel Ángel Cabrera Pérez, Aliuska Morales Helguera, Matheus Froeyen. Pages 2736-2747 Download PDF. Article preview. WebNov 11, 2003 · Concise Synthesis of Cyclothialidine Analogues (VI) with Ring Sizes from 12 to 15: Novel Macrocyclization Protocol Involving Reductive Thiolation. J. Geiwiz, J. Geiwiz. Pharma Div., Chem. Technol., F. Hoffmann-La Roche AG, CH-4070 Basel, Switz. Search for more papers by this author.
WebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest … WebJan 1, 1993 · CYCLOTHIALIDINE, A NOVEL DNA GYRASE INHIBITOR 3.1. DISCOVERY, ISOLATION AND STRUCTURE ELUCIDATION The therapeutic progress achieved with …
WebTheir structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The … WebDec 6, 2024 · 优先权要求. 本申请要求于2024年9月28日提交的美国临时申请no.62/564,820；于2024年3月10日提交的美国临时申请no.62/469,989的权益。
WebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …
WebCyclothialidine (Ro 09-1437) has been considered as a promising inhibitor whose modifications might lead to more potent compounds against the enzyme. We … the piriformis muscleWebCyclothialidine Alternative Names: RO 091437 Latest Information Update: 18 Jul 2000. Price : $50 * Buy Profile. Adis is an information provider. We do not sell or distribute actual drugs. Final gross price and currency may vary according to local VAT and billing address. Your purchase entitles you to full access to the information contained in ... side effects of indicaWebCyclothialidine: ChEBI ID CHEBI:29566: Stars This entity has been manually annotated by a third party. Supplier Information Download Molfile XML SDF: Find compounds which contain this structure; Find compounds which resemble this structure; Take structure to the Advanced Search ... the piripi groupWebCyclothialidine C26H35N5O12S CID 164470 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and … the pirkqlatersWebCyclothialidine D * Please be kindly noted products are not for therapeutic use. We do not sell to patients. Category: Enzyme inhibitors: Catalog number: BBF-01121: CAS: 194276-78-3: Molecular Weight: side effects of indacaterolWebJun 11, 2024 · The effect of cyclothialidine on the DNA supercoiling reaction was antagonized by ATP, reducing the inhibitory activity 11-fold as the ATP concentration was increased from 0.5 to 5 mM. side effects of infliximab infusionWebAug 15, 2007 · From the SAR around cyclothialidine 2 we know that the introduction of a methoxy and a carboxylic ester group in the meta positions and a lipophilic group (like methyl) in para position to the phenol improves activity. Therefore we coupled the salicylic aldehyde 4a with various anilines to yield the acyclic benzylic amines 5 and the 2,3 … side effects of increasing zoloft dosage