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WebApr 18, 2024 · NT5E (CD73) has emerged as a novel target for tumor immunotherapy approaches, since functional inhibition of NT5E reversed its immunosuppressive effects resulting in tumor immune attack and eradication of cancer cells by cytotoxic CD8 + T cells and NK cells. Knowledge about NT5E regulation on the transcriptional and … WebCD73 is a 70 kD glycophosphatidylinositol (GPI)-linked 5'-nucleotidase, which is also known as ecto-5'-nucleotidase. It converts adenosine monophosphate (AMP) to adenosine. CD73 is expressed on subsets of T and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, and epithelial cells. WebAug 1, 2024 · CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune cells. • CD73 has been hijacked by TME to promote tumor growth and metastasis. • Targeting CD73 and other adenosinergic molecules orchestrates anti-tumor immunity. • CD73 blockade achieves synergy in combination with conventional therapy and/or ICB. red hood wattpad