Phosphopantetheine adenylyltransferase
WebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed... WebPhosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer …
Phosphopantetheine adenylyltransferase
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WebNational Center for Biotechnology Information WebPhosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and …
Webpantetheine-phosphate adenylyltransferase Synonyms 3′-dephospho-CoA pyrophosphorylase PPAT dephospho-CoA pyrophosphorylase dephospho-coenzyme A pyrophosphorylase pantetheine phosphate adenylyltransferase Additional information <3, 4> (<3,4> with EC 2.7.1.24 part of a bifunctional enzyme with EC 2.7.1.24 [4,5]) [4, 5] CAS … WebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with …
WebAug 31, 2015 · Inside the cell, 4′-phosphopantetheine was enzymatically converted back to CoA by the bifunctional enzyme CoA synthase. Phenotypes induced by intracellular CoA deprivation were reversed when... WebFeb 7, 2024 · Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution.
WebMar 20, 2024 · Crystal structure of the complex of phospho pantetheine adenylyl transferase from Acinetobacter baumannii with two ascorbic acid (Vitamin-C) molecules. PDB DOI: 10.2210/pdb6JOG/pdb Classification: TRANSFERASE Organism (s): Acinetobacter baumannii Expression System: Escherichia coli Mutation (s): No Deposited: 2024-03-20 …
WebIn enzymology, a pantetheine-phosphate adenylyltransferase ( EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction. ATP + 4'-Phosphopantetheine diphosphate + 3' … sarah jakes and toure robertsWebMar 2, 2024 · Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics … shortys black panthers ceramic bearingWebJan 18, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by … sarah jakes roberts conference 2023WebSep 1, 1999 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. sarah jaffe author and journalistWebFeb 1, 2024 · Phosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and physiologically functional form of ... sarah jakes women evolve conference dallasWebApr 4, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA). sarah jakes roberts first childWebPhosphopantetheine adenylyltransferase (PPAT) cat-alyzes the penultimate step in coenzyme A (CoA) biosyn-thesis: the reversible adenylation of 4*-phosphopante-theine yielding 3*-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. N-terminal sequence analysis revealed sarah jakes roberts outside the system